A pandemic influenza would mean widespread infection essentially throughout every region of the world.

It's the advantage of the virus to spread, and you can only spread when you infect people and they infect other people without necessarily killing them. So if you had 100 percent mortality, the potential pandemic would almost self-eliminate itself.

Even the pandemic flu of 1918 only killed one to two percent of the people who were infected.

You might be asking too much if you're looking for one vaccine for every conceivable influenza. If you have one or two that cover the vast majority of isolates, I wouldn't be ashamed to call that a 'universal vaccine.'

When we can get the incidence of HIV down enough to turn the trajectory of the pandemic, it will assume a momentum of its own in diminishing HIV.

Even in individuals in which we diminished the pool of the reservoir, the hidden reservoir, to levels that were essentially non-detectable ... the virus came right back within two to three weeks in essentially everyone.