By the time the disease was through with him, he no longer knew how to move a chess piece or to put together a simple child's model boat,

Alzheimer's is a devastating disease. It was painful for me and my family to watch my grandfather deteriorate. We must find a cure for this horrible disease.

Maybe it's because I'm getting older, I'm finding enjoyment in things that stop time. Just the simple act of tasting a glass of wine is its own event. You're not downing a glass of wine in the midst of doing something else.

I don't have the time to tell you all the things I've learned from this cast. It's an extraordinary ensemble because we all support each other so well.

I did a big movie this summer, during my hiatus. That's really the time when I can do anything where I have a large part. That was Down With Love, an homage to the Rock Hudson-Doris Day films.

I don't remember any sibling rivalry growing up, because by the time I was really conscious, Tom was going away to college. My relationship with him, which is a very close one, really developed in more recent years.