Confidence of a dedicated person, seems to be over-confidence to ordinary masses.

Doubt not the self O lion-heart, for those who call you crazy will one day worship you.

It does not matter whatsoever, what the people around you think you can or cannot do. What really matters is what you think about your capabilities.

Your fate lies in your hands.

There is no such thing as predestined. Human destiny in the human world is determined by none but the humans.

A Neuroscientist can be the smartest man (or woman) on earth in his understanding of the human mind. He may know all the neurochemical changes underlying an outrageous behavior of a person. But when he gets mad himself, very little of his own scientific intellect would actually come in handy for him to control his rage. The virtue of self-control is a skill, which requires practice, regardless of all the neurobiological expertise in the world.