Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.


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I like New York because you're kind of forced to smell everybody else's funk. So it keeps yo...
JEFFREY WRIGHT
Life, liberty, and the pursuit of happiness is part of our constitutional rights and it belongs to e...
JEFFREY TAMBOR
The tendency to whining and complaining may be taken as the surest sign symptom of little souls and ...
FRANCIS JEFFREY
It was tragic how life had sucked her down to the bones, all her spontaneity her laughter and freedo...
BELINDA JEFFREY
Once I thought I found love, but then I realized I was just out
of cigarettes.
JEFFREY MCDANIEL
We're in a post-conceptual era where it's really the artist's idea and vision that are p...
JEFFREY DEITCH
Wisdom comes when you realize the pain, people, or problems life used to produce you now push you.
JEFFREY FRY
My views tend to be centrist. I'm not a big fan of George W., but my politics tend to be more Re...
JEFFREY SKOLL
We realized that the version of the world they rendered for us was not the world they really believe...
JEFFREY EUGENIDES
I feel I have had a very interesting life, but I am rather hoping there is still more to come. I sti...
JEFFREY ARCHER
The head coach is the chemist.
JEFFREY LURIE
I went into the desert to forget about you. But the sand was the color of your hair. The desert sky ...
JEFFREY EUGENIDES
We Greeks get married in circles, to impress upon ourselves the essential matrimonial facts: that to...
JEFFREY EUGENIDES
And so now, having been born, I'm going to rewind the film, so that my pink blanket flies off, my cr...
JEFFREY EUGENIDES
I was born twice: first, as a baby girl, on a remarkably smogless Detroit day in January of 1960; an...
JEFFREY EUGENIDES
The chief executive officer is also the chief sales officer. He or she is responsible for the succes...
JEFFREY GITOMER
Great leadership involves three things. The ability to realize when you are wrong, a willingness to ...
JEFFREY FRY
I know that attaching memories to books may be going out of the world, but while it lasts, it's ...
JEFFREY EUGENIDES
Concert-going has become much less the thing to do, while people are still going to opera. This migh...
JEFFREY TATE
Stories are great, but at the end of the day, you remember that moment and that moment and that mome...
JEFFREY BELL
Students follow rules. Students complete assignments. The job of students - in part, at least - is t...
JEFFREY TOOBIN
In Asia, a lot of successful economies that had been living on their own saving, decided to open up ...
JEFFREY SACHS
I've been in three sort of... I mean, I'd say they're groundbreaking series, if only bec...
JEFFREY TAMBOR
I was always most interested in drawing - most of my childhood drawings are black-and-white line wor...
JEFFREY BROWN
Marketing is not bragging, and touting one's wares is not evil. The baker in the medieval town s...
JEFFREY ZELDMAN
I actually got thrown into my Bar Mitzvah because my teacher, my Cantor, did not tell me that they w...
JEFFREY TAMBOR
I can't even touch another conductor's baton. The center of gravity, the feel of the handle,...
JEFFREY TATE
I worked at The Old Globe Theater under the great baton of Craig Noel. One of the great theater hero...
JEFFREY TAMBOR
Too often a story is examined through biased eyes, without a sensitivity for everyone who forged it....
JEFFREY WRIGHT
If you're an employer, you want to hire an employee who'll do their job, not do your bidding...
JEFFREY JONES
When I was 14, my dad came home one day and told us he had cancer. It was looking pretty bad. And I ...
JEFFREY SKOLL
Now I'm just like everybody else, and it's so funny,

the way monogamy is funny, the way<...
JEFFREY MCDANIEL
One thing I can give and still keep is my word.
JEFFREY FRY
Fear is caused by the uncertainty of the future. Sorrow is caused by the remembrance of the past. Tr...
JEFFREY FRY
'Gay panic' is insidious. It is corrupt because it appeals to a public that is used to discarding an...
JEFFREY MONTGOMERY
Beware prejudices. They are like rats, and men's minds are like traps; prejudices get in easily, but...
LORD JEFFREY
Andy Warhol defined Pop Art.
JEFFREY DEITCH
Dennis Hopper is one of the great American lives.
JEFFREY DEITCH
Certainly Amadeus because it was a very powerful time for me, we filmed it in the Czech Republic at ...
JEFFREY JONES
Chasing angels or fleeing demons, go to the mountains.
JEFFREY RASLEY
Courtney Vance and I are college classmates, weirdly enough. We're both Harvard class of 1982. C...
JEFFREY TOOBIN
Entrepreneurship does not build character; it reveals character.
JEFFREY FRY
Many of the museum directors who make an impact personally curate exhibitions.
JEFFREY DEITCH
Shine brightly, so you can help those who have not found their path a way through the darkness.
JEFFREY FRY
You know that thing where you're trying to do the crossword puzzle, and you're trying to fit...
JEFFREY TAMBOR
The Quiet World

In an effort to get people to look
into each other’s eyes more, JEFFREY MCDANIEL
We recognize that the typical house built in the 1920s may be smaller than what people want today.
BOB JEFFREY
The scary thing is that over time, as the downtown builds and you start to lose that fabric, once it...
BOB JEFFREY
We'll notify everyone who was signed up.
BOB JEFFREY
After recovering from decades of conflict, Afghanistan needs economic support.
BOB JEFFREY
Wildly successful sites such as Flickr, Twitter and Facebook offer genuinely portable social experie...
JEFFREY ZELDMAN
With consumers buying two smartphones for every desktop computer they purchase, the demands, challen...
JEFFREY ZELDMAN
A short story can be packed with meaning and impact, with the concentrated density of a collapsed st...
JEFFREY THOMAS
Beware prejudices. They are like rats, and men's minds are like traps; prejudices get in easily,...
FRANCIS JEFFREY
A company like DreamWorks, all we do is make product. That's all we do. We don't own distrib...
JEFFREY KATZENBERG
But I certainly made mistakes, for which I regret, I think most human beings in their lifetime make ...
JEFFREY ARCHER