Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.
Jeffrey Kluger
Related From age 16 to age 20, a woman's body is a temple. From 21 to 45, it's an amusement park. Fr... GINA BARRECA I pass the test that says a man who isn't a socialist at 20 has no heart, and a man who is a sociali... WILLIAM CASEY The death of a 20-year-old woman is intuitively worse than that of a 2-month-old girl, even though t... EZEKIEL EMANUEL Although each egg cell produced by a woman carries a single X chromosome, the sperm cells produced b... KENNETH R. MILLER I hate Alzheimer's. It is one of the most awful things because, here is a loved one, this is the... PAT ROBERTSON Most mutations involve typos: Something bumps a cell's elbow as it's copying DNA, and the wr... SAM KEAN When you live with a 20/20 mindset your path is straight, vision is clear, and decisions are precise... FARSHAD ASL The Tour de France is a wicked sport in the way that it's not just man against man or woman agai... BEN FOSTER How lucky I am to have known somebody and something that saying goodbye to is so damned awful. EVANS G. VALENS It's a razor's edge, a romance with an old man and a young woman. PETER O'TOOLE A woman at 20 is like ice, at 30 she is warm and at 40 she is hot. GINA LOLLOBRIGIDA Now, we put out a lot of carbon dioxide every year, over 26 billion tons. For each American, it'... BILL GATES A Ritual to Read to Each Other If you don’t know the kind of person I am and... WILLIAM STAFFORD There's a duality in every man and every woman. RAQUEL WELCH A man has only one escape from his old self: to see a different self in the mirror of some woman'... CLARE BOOTHE LUCE A woman has to be intelligent, have charm, a sense of humor, and be kind. It's the same qualitie... CATHERINE DENEUVE The beauty of a woman may be the root of all evil.
but the beauty is a only seen, your eyes wants to... ARVIND YADAV I think it's important for every man to find the right woman and every woman to find the right m... JAKE GYLLENHAAL It is an old error of man to forget to put quotation marks where he borrows from a woman's brain... ANNA GARLIN SPENCER When it comes to spotting a blonde hair on a man's coat, every wife has 20-20 vision. SOURCE UNKNOWN I totally agree with equal rights and women's causes, and most of my songs are woman-power, but ... MEGHAN TRAINOR I'm fascinated by the journey that an intelligent and an ambitious woman makes in the profession... CHARLES CUMMING We have to abandon the idea that schooling is something restricted to youth. How can it be, in a wor... ARTHUR C. CLARKE The way I use to develop an aerobic condition is three against three, man to man, in a square 20 met... JOSE MOURINHO There's a whole form of literature in India which talks about the quest for the perfect man by a... SHAH RUKH KHAN The scientific method gives us
information by testing and repeating observable things so that we
can... LEWIS N. ROE The role of the
Christian is to let other people know what Jesus has done, not to
think of themselve... LEWIS N. ROE Naturalistic atheism debunks itself. It
has no power to explain even some
of the most basic principl... LEWIS N. ROE It's important to understand that if
someone calls themselves a Christian, it does not automatically... LEWIS N. ROE The more aware a man is of a woman's body, the better. He needs to know he has to tend to a woma... RACHEL BILSON For a two-hour movie on a 20-day shooting schedule, it's O.K. to have an actor who's a pain ... DAVID L. WOLPER A woman's experience is different from a man's in virtually every respect, including how she... CARLY FIORINA I live by a man's code, designed to fit a man's world, yet at the same time I never forget t... CAROLE LOMBARD A 20/20 mindset produces uncontainable joy and peace. These fruits allow you to live more creatively... FARSHAD ASL A 20/20 mindset eradicates any source of fear, doubt, and uncertainty. It produces a balanced life i... FARSHAD ASL Plunging in “truths” about God is like walking on the bottom of a sea that is not there, searchi... MARIANA FULGER It's incredibly unfair. You don't see a lot of 60-year-old women with 20-year-old men onscre... GEORGE CLOONEY People between 20 and 40 are not sympathetic. The child has the capacity to do but it can't know. It... WILLIAM FAULKNER The alpine environment is very delicate. I've been able to see change in the mountains in the 20... CONRAD ANKER A man has every season while a woman only has the right to spring. JANE FONDA A man has to be Joe McCarthy to be called ruthless. All a woman has to do is put you on hold. MARLO THOMAS 'Hannity' had a a guy on that said, 'I fathered 20 kids by 14 mothers.' That is s cu... FOSTER FRIESS Cheap is the love that has a price. LJUPKA CVETANOVA Stop thinking, and end your problems. What difference between yes and no? What difference ... LAO TZU Women of child-bearing age steadily run out of eggs by the continuous process of cell death. While r... ROBERT WINSTON It's not common for a woman on television, especially if she's the mom of the family, to be ... MARTHA PLIMPTON Curran's whore comes to visit us," Jarek said in accented English. The three men laughed ... ILONA ANDREWS Fragrance takes you on a journey of time. You can walk down the street and pass someone and get take... DAPHNE GUINNESS We have to abandon the idea that schooling is something restricted to youth. How can it be, in a wor... ARTHUR C. CLARKE My films are about ideals that clash with the world. Every time it's a man in the lead, they hav... LARS VON TRIER A coin is examined, and only after careful deliberation, given to a beggar, whereas a child is flung... PETER WESSEL ZAPFFE Empathy is the new measurement of everything. It doesn't matter what religion you have, what God you... C. JOYBELL C. Eventually I came across another passage. This is what it said: I am not commanding you, but I ... NICHOLAS SPARKS To kill a mockingbird. If you haven't read it, I think you should because it is very interesting. STEPHEN CHBOSKY I will never forget the vision of Jamie walking towards me. NICHOLAS SPARKS As these images were going through my head, my breathing suddenly went still. I looked at Jamie, the... NICHOLAS SPARKS You don't have to learn much out of books, it's like if you want to learn about cows, you go milk on... HARPER LEE You can't really get to know a person until you get in their shoes and walk around in them. HARPER LEE My Soul to Keep is the ultimate love story with a black man and a black woman. I call it the ultimat... BLAIR UNDERWOOD There is some uncertainty in the total influx of meteoric matter, but it is probably on the order of... ANDREW KLEKOCIUK There's good and bad in everybody. I wasn't looking for the good, or looking for the bad. Th... SAM MENDES When you have 20 nominations - 20 names on the nomination list of best actor, supporting actor and a... TONY CARDENAS To the old saying that man built the house but woman made of it a 'home' might be added the ... EMILY POST You release the pain of the past and press on. It's a new day, and God is doing a new thing. He want... CRAIG GROESCHEL If someone's intimidated by me, that's something they have to deal with. When I walk down th... VING RHAMES You must have traveled all night,” she heard herself say. “I had to come back early.” Sh... LISA KLEYPAS I wasn't even 20 at the time, but it taught me something about drugs. They can take a good man, ... MICHAEL BERGIN I want to play a range, from victims to strong people, just as long as it's a well-rounded chara... BEL POWLEY He eventually has to carry the torch; it is just a matter of time. I am 72 years old. I hope to live... CARMEN SALVINO It takes a CONSTANT flowing of gas from the cylinder to keep the fire burning under your pot. “WOO... OLAOTAN FAWEHINMI Marriage was all a woman's idea and for man's acceptance of the pretty yoke, it becomes us t... PHYLLIS MCGINLEY Somewhere in that 20-year period, I would assume that there will be some basically new approach that... JACK KILBY Nothing has gotten me out of Philadelphia. I moved 20 minutes away from Philly. That's about it. JILL SCOTT The atheist might have
no proof for the
supernatural, but they
also have no proof
against it. If we ... LEWIS N. ROE I have met so many heartbroken men. It's a catastrophe. Women are easily overcome by the process tha... C. JOYBELL C. A man has every season while a woman only has the right to spring. That disgusts me. JANE FONDA I don't want to let my life as a woman pass me by. There's a time to work, there's a tim... DIANE KRUGER AARP knows the future is bright for a generation that's going to remain healthy and vital for 10... JANE PAULEY Love is the whole history of a woman's life, it is but an episode in a man's. MADAME DE STAEL 'The Haunted Man' is about communication barriers between men and women, and in that song it... BAT FOR LASHES If there's a country, and it's dangerous, and we deploy a U.S. military man or woman, if the... JOHN F. KELLY If a man loves you... he's willing to profess it. He'll give you a title after a while. You&... STEVE HARVEY Phenomenal, man, 20 boards is a lot. He had 20 and 20. I've never played with a guy who's done that ... BRANDON HEATH You don't have to be age 20 and size zero to be sexually viable or viable as a woman. BELINDA CARLISLE No man is offended by another man's admiration of the woman he loves; it is the woman only who c... JANE AUSTEN I feel so honored to be able to say "What I do is for my son" without that being an excuse to do stu... C. JOYBELL C. This is what's sick about living in L.A. My eight-year-old daughter will point to a woman and sa... KATE BECKINSALE Only four of the current 20-man squad for this last match will be too old for the next campaign, so ... BRIAN FLYNN A woman can't be alone. She needs a man. A man and a woman support and strengthen each other. Sh... MARILYN MONROE Women are just beginning to see that; there's something about being a woman that's innately ... KENNY LOGGINS In a world where pleasure rules, people tend to be undeveloped in every way. " A House Like a Lotus MADELEINE L’ENGLE Temptation is a woman's weapon and man's excuse. H. L. MENCKEN In New York, the average total state and local tax burden is $5,260 for every man, woman and child. ... TOM GOLISANO Every time it gives you hope, a big old nasty cloud rolls over you and hails on you in April. It dum... BRIAN CHAMPION About 20 years ago not every man used a deodorant, DYLAN JONES Every time you see a black romance, it's over-the-top. There always has to be extreme hostility ... BERNIE MAC A man doesn't know what it's like to be a woman; it's that simple. TRACEY EMIN Everyone has something that they desperately need that makes them feel good, that they don't wan... TASHA SMITH I will never be the woman with the perfect hair, who can wear white and not spill on it. SEX AND THE CITY The Hebrew Bible, while firmly opposing pagan sexual practices, nevertheless celebrates man's an... MEIR SOLOVEICHIK
More Jeffrey Kluger
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The ability to realize when you are wrong, a willingness to ... JEFFREY FRY I know that attaching memories to books may be going out of the world, but while it lasts, it's ... JEFFREY EUGENIDES Concert-going has become much less the thing to do, while people are still going to opera. This migh... JEFFREY TATE Stories are great, but at the end of the day, you remember that moment and that moment and that mome... JEFFREY BELL Students follow rules. Students complete assignments. The job of students - in part, at least - is t... JEFFREY TOOBIN In Asia, a lot of successful economies that had been living on their own saving, decided to open up ... JEFFREY SACHS I've been in three sort of... I mean, I'd say they're groundbreaking series, if only bec... JEFFREY TAMBOR I was always most interested in drawing - most of my childhood drawings are black-and-white line wor... JEFFREY BROWN Marketing is not bragging, and touting one's wares is not evil. The baker in the medieval town s... JEFFREY ZELDMAN I actually got thrown into my Bar Mitzvah because my teacher, my Cantor, did not tell me that they w... JEFFREY TAMBOR I can't even touch another conductor's baton. The center of gravity, the feel of the handle,... JEFFREY TATE I worked at The Old Globe Theater under the great baton of Craig Noel. One of the great theater hero... JEFFREY TAMBOR Too often a story is examined through biased eyes, without a sensitivity for everyone who forged it.... JEFFREY WRIGHT If you're an employer, you want to hire an employee who'll do their job, not do your bidding... JEFFREY JONES When I was 14, my dad came home one day and told us he had cancer. It was looking pretty bad. And I ... JEFFREY SKOLL Now I'm just like everybody else, and it's so funny, the way monogamy is funny, the way<... JEFFREY MCDANIEL One thing I can give and still keep is my word. JEFFREY FRY Fear is caused by the uncertainty of the future. Sorrow is caused by the remembrance of the past. Tr... JEFFREY FRY 'Gay panic' is insidious. It is corrupt because it appeals to a public that is used to discarding an... JEFFREY MONTGOMERY Beware prejudices. They are like rats, and men's minds are like traps; prejudices get in easily, but... LORD JEFFREY Andy Warhol defined Pop Art. JEFFREY DEITCH Dennis Hopper is one of the great American lives. JEFFREY DEITCH Certainly Amadeus because it was a very powerful time for me, we filmed it in the Czech Republic at ... JEFFREY JONES Chasing angels or fleeing demons, go to the mountains. JEFFREY RASLEY Courtney Vance and I are college classmates, weirdly enough. We're both Harvard class of 1982. C... JEFFREY TOOBIN Entrepreneurship does not build character; it reveals character. JEFFREY FRY Many of the museum directors who make an impact personally curate exhibitions. JEFFREY DEITCH Shine brightly, so you can help those who have not found their path a way through the darkness. JEFFREY FRY You know that thing where you're trying to do the crossword puzzle, and you're trying to fit... JEFFREY TAMBOR The Quiet World In an effort to get people to look into each other’s eyes more, JEFFREY MCDANIEL We recognize that the typical house built in the 1920s may be smaller than what people want today. BOB JEFFREY The scary thing is that over time, as the downtown builds and you start to lose that fabric, once it... BOB JEFFREY We'll notify everyone who was signed up. BOB JEFFREY After recovering from decades of conflict, Afghanistan needs economic support. BOB JEFFREY Wildly successful sites such as Flickr, Twitter and Facebook offer genuinely portable social experie... JEFFREY ZELDMAN With consumers buying two smartphones for every desktop computer they purchase, the demands, challen... JEFFREY ZELDMAN A short story can be packed with meaning and impact, with the concentrated density of a collapsed st... JEFFREY THOMAS Beware prejudices. They are like rats, and men's minds are like traps; prejudices get in easily,... FRANCIS JEFFREY A company like DreamWorks, all we do is make product. That's all we do. We don't own distrib... JEFFREY KATZENBERG But I certainly made mistakes, for which I regret, I think most human beings in their lifetime make ... JEFFREY ARCHER