[George Clooney donated $1 million to the United Way for hurricane relief.] There isn't much any of us can do right now but pour money into this tragedy, ... We're all in this one together.

You have to remember that in the microcosm of Cincinnati, Ohio, through northern Kentucky, my father was a big star, still is. So that made my sister and me really visible. Everybody knew us, talked about us.

The idea that every time you do a film you're supposed to be tortured confuses me. I mean, guys who say, 'Oh, it's really tough, my character is really suffering' -come on. For us, even in the rotten ones we've had a good time. I don't think you have to suffer.

There is a strange pecking order among actors. Theatre actors look down on film actors, who look down on TV actors. Thank God for reality shows, or we wouldn't have anybody to look down on.

I use my film-making to work through my deep questions and my deep problems. I think I could watch each film and tell you exactly which part of my psyche I'm trying to work out.

After doing One Fine Day and playing a pediatrician on ER, I'll never have kids. I'm going to have a vasectomy.