Many entrepreneurs that made their fortunes by founding successful technology companies want to give back and solve the world's biggest problems on a grand scale. There is tremendous opportunity in this approach.

The world's biggest problems are the world's biggest market opportunities. And that's a huge thing. Solve hunger, literacy and energy problems, get the gratitude of the world and become a billionaire in the process.

It used to be that the only ones with access to cutting-edge technology were top government labs, big companies and the ultra-rich. It was simply too expensive for the rest of us to afford.

Companies have too many experts who block innovation. True innovation really comes from perpendicular thinking.

Many people who try to do big bold things in the world find out it's not about the money or the technology: It's about the regulatory hurdles that will try and stop you.

Future companies will be smaller and more nimble.