No one has seen these results before with any regimen over any period of time. They can't get any better.

Vertex achieved all of its clinical, research and financial objectives in 2005. In particular, we increased our financial strength as we advanced potentially transformational compounds targeting hepatitis C virus (HCV), rheumatoid arthritis and cystic fibrosis. Our performance last year has positioned us to build momentum in 2006.

Vertex's cystic fibrosis research program has yielded two innovative approaches for the treatment of this disease.

After last week, I think our mentality is where it was last year at this time, and even better. We are going to go in and get after it.

The male singers are spending a lot more time singing with the females.

We're staffed to deal with thousands of calls, as long as they don't all come at the same time.