One's ideas must be as broad as Nature if they are to interpret Nature

A study in scarlet, eh? Why shouldn't we use a little art jargon? There's the scarlet thread of murder running through the colourless skein of life, and our duty is to unravel it, and isolate it, and expose every inch of it.

It is not my intention to be fulsome, but I confess that I covet your skull.

For strange effects and extraordinary combinations we must go to life itself, which is always far more daring than any effort of the imagination.

As a rule, said Holmes, the more bizarre a thing is the less mysterious it proves to be. It is your commonplace, featureless crimes which are really puzzling, just as a commonplace face is the most difficult to identify.

You will, I am sure, agree with me that... if page 534 only finds us in the second chapter, the length of the first one must have been really intolerable.