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Our experimental results agreed with the computational findings, indicating that these ratchetting points mediate the removal of intron subfragments in one direction as the gene is transcribed initially from DNA into RNA,


Javier Lopez

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Our experimental results agreed with the computational
findings, indicating that these ratchett...
JAVIER LOPEZ The striking evolutionary conservation of ratchetting points suggests that recursive splicing provid...
JAVIER LOPEZ The striking evolutionary conservation of ratchetting points
suggests that recursive splicing p...
JAVIER LOPEZ RNase H is a specific RNase that will cleave the RNA of a DNA/RNA duplex.
CAROL W. GREIDER This last discovery illuminated the mechanism of protein synthesis: the protein chain is transferred...
WALTER GILBERT ... I had stayed still and let the days pass, which is the best way to allow things in the real worl...
JAVIER MARíAS Knowing the structure of Dicer sets the stage for understanding how Dicer enzymes are involved in ot...
JENNIFER DOUDNA Many molecules are known that interfere with reading, or transcribing, genes' DNA to get RNA. But no...
LIU JUN The universe seeks equilibriums; it prefers to disperse energy, disrupt organization, and maximize c...
SIDDHARTHA MUKHERJEE The problem with the gene pool is that there's no lifeguard.
DAVID GERROLD To have the time to reminisce is one of the futures gifts. Don't think to much, don't live to fast, ...
CALVIN WILSON We are the masters of our own destinies we shape and mould our lives into to the circumstances surro...
GARY F EVANS... These proposed missions are very cost effective ways to provide new results that can be directly com...
MICHAEL A'HEARN Dive into the river of the present, but don't thrash about, go with the flow.
JIM GENOVESE I'm fucking the grave, I thought, I'm bringing the dead back to life...
CHARLES BUKOWSKI With this crystal structure, we've learned that Dicer serves as a molecular ruler, with a clamp at o...
JENNIFER DOUDNA For me that's the only way of understanding a particular term that everyone here bandies about quite...
JAVIER MARíAS The findings may point the way to new medical interventions, such as drugs or vaccines, for infectio...
ANTHONY S. FAUCI Life can be tough & make you wanna give up. But baby keep your head up because you got all the time ...
LILLIAN S. VILORIA These findings are new to science. The contribution we have made is showing that neuroD2 is related ...
JAMES OLSON Maybe that's what it all comes down to. Love, not as a surge of passion, but as a choice to commit t...
EMILY GIFFIN We initially started with earthquakes, ... One of the critical points is that the lower floor plus t...
FRITZ GAMPE We show how the normal function of the gene keeps dopamine cells from dying. If the gene is abnormal...
DR. CURT FREED His words even imply that philanthropy has deeper depths than is generally realized. The great emoti...
FULTON J. SHEEN In network models of the interactome, these truncating mutations can be thought of as the removal of...
JOSEPH LOSCALZO I would hope that these results, combined with similar recent findings, would encourage scientists t...
BRUCE FLAMM I like to open for a band as it brings on sort of a challenge and it makes things more interesting. ...
KELLY JONES It seems likely that most if not all the genetic information in any organism is carried by nucleic a...
FRANCIS CRICK He called out to his fellow monks,'Come quickly I am tasting stars.
JOHN GREEN Every revolution begins with one voice crying in the wilderness.
JEFFREY FRY The region of DNA identified in our study showed evidence of replication in four independent series ...
ALISON GOATE The region of DNA identified in our study showed evidence of replication in four independent series ...
ALISON M. GOATE Before you dive in head first, make sure the water is not shallow.
KATHERINE DIVOLIS What else? She is so beautiful. You don’t get tired of looking at her. You never worry if she is s...
JOHN GREEN Pero diré esto: Cuando los científicos del futuro aparezcan en mi casa con ojos robot y me digan q...
JOHN GREEN Wow,” I said. “Are you making this up?”
“Hazel Grace, could I, with my meager intellect...
JOHN GREEN Finally, I decided that the proper strategy was to stare back. Boys do not have a monopoly on the St...
JOHN GREEN We were sitting there on the couch together, and he pushed himself up to go but then fell back down ...
JOHN GREEN So it’s your death suit.”
“Correct. Don’t you have a death outfit?”
“Yeah,”...
JOHN GREEN I spent your Wish on that doucheface,” I said into his chest.
“Hazel Grace. No. I will gran...
JOHN GREEN «Hazel Grace,” he said, my name new and better in his voice. “It has been a real pleasure to ma...
JOHN GREEN Cold,” he said, pressing a finger to my pale wrist.
“Not cold so much as underoxygenated,�...
JOHN GREEN If he is anything other than a total gentleman, I’m going to gouge his eyes out.”
“So you...
JOHN GREEN People always get used to beauty, though.”
“I haven’t gotten used to you just yet,” he ...
JOHN GREEN Augustus: “You probably need some rest.”
Me: “I’m okay.”
Augustus: “Okay.” (...
JOHN GREEN Time's a slut, she screws with everyone.
JOHN GREEN como toda pregunta sobre el universo, esta vía de investigación nos obliga inevitablemente a pregu...
J.K. ROWLING No puedes escoger si serás lastimado en este mundo, pero si puedes decidir quién te lastima
JOHN GREEN But it's your life.
JOHN GREEN No matter how hard you kick, no matter how high you get, you can't go all the way round.
JOHN GREEN Cancer kids are essentially side effects of the relentless mutation that made the diversity of life ...
JOHN GREEN No puedes elegir si van hacerte daño en este mundo, pero sí eliges quién te lo hace.
JOHN GREEN you clench your teeth,you look up, you tell yourself that if they see you cry, it will hurt them,and...
JOHN GREEN That's the think about pain. It demands to be felt.
JOHN GREEN Seriously, don't even get me started on my hot bod. You don't want to see me naked, Dave. seeing me ...
JOHN GREEN Writing does not resurrect. It buries..
JOHN GREEN Pero diré esto: Cuando los científicos del futuro aparezcan en mi casa con ojos robot y me digan q...
JOHN GREEN You’re arguing that the fragile, rare thing is beautiful simply because it is fragile and rare. Bu...
JOHN GREEN So how’s it going?”
“Okay. Glad to be home, I guess. Gus told me you were in the ICU?”<...
JOHN GREEN Still perfect,” he said. “Read to me.”
“This isn’t really a poem to read aloud when y...
JOHN GREEN All believers are members of the same body and should be viewed and treated that way.
HENRY HON This is the first experimental proof that under some reasonable operating conditions these cantileve...
ARVIND RAMAN I want the world to bleed when it brushes up against me.
JONATHAN DOUGLAS DURAN All day long you sit and sew,
Stitch life down for fear it grow,

Stitch life down fo...
EDITH SITWELL As long as that song plays, I get to put my hands on you, and I can’t guarantee I’m going to be ...
MEREDITH WILD Just give me one night, Vanessa. One night, and I won’t let you regret it.
MEREDITH WILD We can leave a place behind, or we can stay in that place and leave our selfishness (often expressed...
JOHN H. GROBERG She buys "mixed salad greens" for seven dollars a bag, triple-washed with who knows what. And to get...
RUDOLPH DELSON The (EU) member states agreed in March at the European summit in Brussels that this should be part o...
ULRICH WILHELM The battle is not physical, it is spiritual and your mind is the battleground. Keep your mind pure a...
JEANETTE CORON Right now, the techniques for gene therapy are kind of brute force. You put the gene in and hope it ...
HARVEY LODISH I am frequently astonished that it so often results in correct predictions of experimental results.
MURRAY GELL-MANN The company's sequential sales performance benefited from growth in digital consumer and automotive ...
CARLO BOZOTTI She was intimidating and all I could do was sit back on the couch as she paced back and forth, slowl...
IN THE MAKING As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been suppor...
EDWARD LAWRIE TATUM Great balls of fire. Don't bother me anymore, and don't call me sugar.
MARGARET MITCHELL I travel to know where I fit into the world, and where I don’t.
CAREW PAPRITZ Sometimes he did not know if he slept or just thought about sleep.
MARK STRAND We cannot know what time will do to us with its fine, indistinguishable layers upon layers, we canno...
JAVIER MARíAS She said 'Over my dead body!' so I took her at her word.
DIANA WYNNE JONES The end of the world is a strange concept. The world is always ending, and the end is always being a...
NEIL GAIMAN What is the Other?" they ask.
The Other is the one who taught me whatI should be like, but not ...
PAULO COELHO Life begins somewhere and ends somewhere with time but to get somewhere with the life you have depen...
ERNEST AGYEMANG YEBOAH These young ones. They do not understand. There are so few of us left who remember how destructive r...
CONNILYN COSSETTE Civilised life, you know, is based on a huge number of illusions in which we all collaborate willing...
J.G. BALLARD The true clinical importance of our findings, in which patients and practitioners need to balance th...
DAVID MARGOLIS When you live in the present, the past is forgotten & the future takes care of itself.
MANDY HALE DNA gets everywhere. So when we're dealing with a sample and you find it's got human DNA in it - is ...
CHRIS STRINGER In comparing various authors with one another, I have discovered that some of the gravest and latest...
PLINY THE ELDER (HIV) is a retrovirus, and one that has the capability of inserting itself into a gene -- into the g...
ANTHONY FAUCI Our study shows that DNA itself can act as a mutagen, resulting in genetic instability. The discover...
KAREN VASQUEZ Well, I'm more lopsided than a one legged badger," mewed Graypaw, breaking off from his carful stalk...
ERIN HUNTER No milk. It is black coffee, pure but strong, that fortifies against the powers of darkness with whi...
ROBERT AICKMAN I thought climbing the Devil's Thumb would fix all that was wrong with my life. In the end, of cours...
JON KRAKAUER I don't know if I have a favorite color.
KATE MIDDLETON It's very special having a new little girl.
KATE MIDDLETON To get over the past, you first have to accept that the past is over. No matter how many times you r...
MANDY HALE Look, my friends!' he called. 'Here's a pretty hobbit-skin to wrap an elven princeling in! If it wer...
J.R.R. TOLKIEN Horror as for me is the best choice, you can gain a lot of. I like to be afraid like to see this shi...
DEYTH BANGER There is no greater glory than to die for love.
GABRIEL GARCíA MáRQUEZ

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JAVIER VAZQUEZ I'm glad I could get out of trouble when I was in it,
JAVIER VAZQUEZ There's other guys here and I know they want to pitch every five days, too, so it's not just me.
JAVIER VAZQUEZ I don't like it. But what can I do? I want to pitch every fifth day and they know that, but it's not...
JAVIER VAZQUEZ I wanted to pitch. I thought I could pitch. The doctor said because I've lost a lot of fluids the pa...
JAVIER VAZQUEZ I just battled out there. The balls just found the holes. I just felt like I was in trouble all nigh...
JAVIER VAZQUEZ It's just disappointing to be losing all these games, man. It's really frustrating. We're not gettin...
JAVIER VAZQUEZ A change-up right down the middle, ... You've got to hit that pitch.
JAVIER VALENTIN I don't know, man. ... What can I say?
JAVIER VALENTIN He made good adjustments after the first two innings. When he gives us more than six innings, we hav...
JAVIER VALENTIN I've been really happy about the way the team has come around in the second half of the season, ... ...
JAVIER VALENTIN I've been trying to shorten my swing a bit more, ... I'm also trying to see the ball more. That's th...
JAVIER VALENTIN You don't know what's going to happen on a play like that,
JAVIER VALENTIN I didn't know what part of my body he hit. But in the morning - my shoulder.
JAVIER VALENTIN He's going to give me one pitch to hit. That's why it's a situation where I can't miss that pitch. B...
JAVIER VALENTIN He's going to try to be careful with me and he's only going to give me one pitch to hit, ... In that...
JAVIER VALENTIN I'll be all right,
JAVIER VALENTIN We are just hoping that this is our year. We have a great team out here and we're confident we can m...
JAVIER TORRES I got a little bit frustrated there at the end of the game, but I knew my defense would help me out.
JAVIER TORRES He really helped me a lot out there tonight. Since he's a pitcher himself, he knows what to tell me ...
JAVIER TORRES I have to give a lot of credit to the defense. Our defense is our greatest strength right now and th...
JAVIER TORRES I hope the player continues to show the same scent for goal that he is showing now, and that he goes...
JAVIER SUBIRATS In this moment, we have presented an offer to player and, until now, we have not had a response.
JAVIER SUBIRATS