These benefits were seen in women who had consistently used hormone therapy and had been in menopause for at least five years.

The paradigm of treating menopause symptoms with the lowest effective dose of hormone therapy, for the shortest period necessary, is very sensible.

We don't believe hormone therapy will make wrinkles melt away once they're already there, but the results of our study shows that hormone therapy can prevent them. Hormone therapy makes wrinkles less severe and keeps skin more elastic.

Together with that was the women who were receiving hormone therapy had a greater occurrence of leg clots, deep vein leg thrombosis and a sizeable increase in gall bladder disease. So we began to see adverse effects and no benefit, and this really raised concern,

We will examine the condition of their arteries before, during and after therapy, and compare it to women on no therapy to see if the hormones cause or prevent changes leading to heart disease.

Women should also talk to their doctors about hormone replacement therapy
once they reach menopause, ... We should have more information in
several years about different doses and hormone combinations, so a woman's
regimen can be more tailor-made.