They have a very low metabolism. I don't believe you could sedate them. Besides, you don't really want to sedate them because it's not going to be a good show gator if he's just lying there half-dead. You want the most active gator possible. You try not to overuse him, so he doesn't lame out on you.

Greg Long

Believe Besides Low Metabolism Sedate

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I've never got beside one and run with it. But usually when they make a burst for the water, it's lightning fast.