This 'foot in the door' mechanism of drug binding and action is a relatively new way of thinking about things, arising from the greater appreciation of proteins as dynamic molecular machines.

The mischief springs from the power which the monied interest derives from a paper currency which they are able to control, from the multitude of corporations with exclusive privileges which they have succeeded in obtaining...and unless you become more watchful in your states and check this spirit of monopoly and thirst for exclusive privileges you will in the end find that the most important powers of government have been given or bartered away….
- Andrew Jackson, Farewell Address, 1837

Everybody wants to be somebody; nobody wants to grow.

Anything done without thinking is dangerous.

First you must know what to do, then you must do it.

Thinking needs action; action needs thinking.