We don't know at this point whether these are going to be permanent episodes of heart damage or transient,

Clearly, the results reported in this issue of the journal are revolutionary.

Clearly, the results are not evolutionary but revolutionary.

Our care of patients with HER2-positive breast cancer must change today,

The results are simply stunning, ... will completely alter our approach to the treatment of breast cancer.

The strength of the evidence is so overwhelming at this point that it would be almost impossible to withhold this drug from the appropriate group of patients.