What the deuce is it to me? he interrupted impatiently; "you say that we go round the sun. If we went round the moon it would not make a pennyworth of difference to me or to my work."

Skill is fine, and genius is splendid, but the right contacts are more valuable than either.

I never make exceptions. An exception disproves the rule.

You have probably never heard of Professor Moriarty? said he.

I never remember feeling tired by work, though idleness exhausts me completely

When the spirits are low, when the day appears dark, when work becomes monotonous, when hope hardly seems worth having, just mount a bicycle and go out for a spin down the road, without thought on anything but the ride you are taking.