Part of it is the responsibility of patients and part of it is physicians and trying to keep up with the latest guidelines for how intensively to treat high blood pressure and high cholesterol.

I think that physicians have a responsibility to return these devices, or they can encourage families to return the devices to the manufacturer. We've been talking about this for 30 years ... Unfortunately, the devices end up in the hands of the lawyers.

The overall findings were negative, but a benefit was seen in patients with established cardiovascular disease.

Aspirin is tough to beat, but it too has bleeding risk.

There is no reason to use the combination therapy for primary prevention, whereas it might be useful in patients who have already had a heart attack or stroke.

I'd say that I, as well as our other investigators, were surprised at the findings.