There is no reason to use the combination therapy for primary prevention, whereas it might be useful in patients who have already had a heart attack or stroke.

Part of it is the responsibility of patients and part of it is physicians and trying to keep up with the latest guidelines for how intensively to treat high blood pressure and high cholesterol.

The overall findings were negative, but a benefit was seen in patients with established cardiovascular disease.

Aspirin is tough to beat, but it too has bleeding risk.

I'd say that I, as well as our other investigators, were surprised at the findings.

You'd like to think if somebody had the big one that they would realize that now is really the time to stop smoking. I think this shows that it?s not as easy as we maybe like to think it is.